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By interacting with the Lys140 residue of NIMA-related kinase 7 (NEK7), A20 and its derivative peptides hinder the NEK7-NLRP3 interaction, suppress macrophage STING signaling and NLRP3-mediated pyroptosis, and thereby effectively relieve auto-DNA-induced AKI [179]

Firstly, we advocate for the development of drugs aimed at optimizing mitochondrial energy metabolism

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